Functional Genomic Analysis, Parts 1,2 & 3: Why NADPH Deficiency May be the Missing Link in Detoxification from Environmental Toxins

Bob Miller is a Traditional Naturopath specializing in the field of genetic-specific nutrition.  Dr Miller is one of the leaders in the field of Genomics. For the past several years, he has been engaged exclusively with functional nutritional genetic variants and related research, specializing in nutritional support for those with chronic Lyme disease.  Bob is the founder Functional Genomic Analysis, an online software program that organizes and analyzes genetic SNPs for functional health professionals.

EHS WEBINAR PART ONE: Genetics and Epigenetics: Why NADPH Deficiency May be the Missing Link in Detoxification from Environmental Toxins, moderated by Tom Malterre CN (1:10, recorded February 27)

Learn about the relationship between environmental and other epigenetic factors and an individual’s genetics to better understand the role genetics may play in patient wellness. NADPH is needed for recycling antioxidants, creating Nitric Oxide and many other critical functions. In this webinar, we will examine the many roles of NADPH, and how genetic and epigenetic factors may be depleting it.

EHS WEBINAR PART 2 How Overexpression of the NOX Enzyme is Creating the "NADPH Steal"  (35:52, recorded March 12)  Includes an introduction by Dr Lyn Patrick to set the context.

The NOX (NADPH Oxidase Enzyme) is critical for fighting infection. However, if it is upregulated by epigenetic and genetic factors, it can create excess mast cell activity and slow the recycling of antioxidants and impar nitric oxide production, thus leading to impaired detoxification ability. In this webinar, we review the genetic and epigenetic factors that can create this condition, and how to compensate for it.

EHS WEBINAR PART 3 How Dysregulation of Iron is Contributing to Inflammation and Poor Detoxification of Environmental Toxins  (41:53, recorded March 12) Includes an introduction by Dr Lyn Patrick to set the context.

Although Iron is critical for many functions, genetic and epigenetic factors can allow Iron to become a Hydroxyl Radical, consequently creating excess inflammation and decreased antioxidant capacity that is needed for detoxification. In this webinar, we show how to identify and take corrective action if this is occurring.

References

To access the following articles go to pubmed.ncbi.nih.gov and put the PMID number (without PMID) in search bar.

Iron Dysregulation 

Bloomer SA, Brown KE. Iron-Induced Liver Injury: A Critical Reappraisal. Int J Mol Sci. 2019;20(9):2132. PMID: 31052166 

Calderón-Garcidueñas L, González-Maciel A, Kulesza RJ, et al. Air Pollution, Combustion and Friction Derived Nanoparticles, and Alzheimer's Disease in Urban Children and Young Adults. J Alzheimers Dis. 2019;70(2):343–360. PMID: 31256139 

Calderón-Garcidueñas L, Gónzalez-Maciel A, Reynoso-Robles R, et al. Hallmarks of Alzheimer disease are evolving relentlessly in Metropolitan Mexico City infants, children and young adults. APOE4 carriers have higher suicide risk and higher odds of reaching NFT stage V at ≤ 40 years of age. Environ Res. 2018;164:475–487. PMID: 29587223 

Calderón-Garcidueñas L, González-Maciel A, Mukherjee PS, et al. Combustion- and friction-derived magnetic air pollution nanoparticles in human hearts. Environ Res. 2019;176:108567. PMID: 31344533 

Overexpression of NOX (NADPH oxidase) 

Barua S, Kim JY, Yenari MA, Lee JE. The role of NOX inhibitors in neurodegenerative diseases. IBRO Rep. 2019;7:59–69. PMID: 31463415