A wide variety of degenerative processes, syndromes and diseases, have been associated with oxidative stress. Oxidative stress is a biological response to endogenous and exogenous exposures. Numerous environmental chemicals and drugs can initiate or exacerbate oxidative stress leading to the development of adverse outcomes. The antioxidant defense systems play a key role preventing oxidative stress damage and slowing down the progression of pathological conditions.
My research interests focus on oxidative stress and the role of paraoxonases 1, 2 and 3 in preventing chronic human disease. My current research projects include:
- Proteomics analysis of biomarkers of organophosphorus exposures
- Paraoxonases-1 and -2 in neurotoxicity caused by heavy metal exposures
- Study of paraoxonase-1 as a biomarker of cardiovascular disease and Alzheimer’s disease
- Study of a novel homocysteine thiolactonase in induced hyperhomocysteinemia
My educational background includes a B.A. in Biochemistry from the University Autonoma of Barcelona and a Ph.D. in Biochemistry from the University Rovira i Virgili, both in Spain. I carried out my postdoctoral studies at the University of Washington where I currently hold a junior faculty position in the Division of Medical Genetics (Department of Medicine).